Beta-Hydroxybutyrate (β-OHB)

Food Sources

Foods that contain Beta-Hydroxybutyrate (β-OHB).

• Ketogenic diet

  KD leads to elevated levels of circulating β-OHB

  Source: Nutrition, Food and Diet in Ageing and Longevity

Biological Mechanisms

How Beta-Hydroxybutyrate (β-OHB) works at a cellular level.

• PromotesBlocks the NLRP3 inflammasome that triggers inflammatory signals

  NLRP3 inflammasome which regulates caspase-1 activation and release of pro-inflammatory cytokines IL-1β and IL-18 is prohibited by ketones

• PromotesInhibits histone deacetylases restoring gene expression

  β-OHB inhibited histone deacetylases such as 1, 3 and 4, restoring memory function and improving synaptic plasticity

• PromotesProvides alternative brain fuel

  Brain utilizes KBs synthesized in the liver as an energy source during KD; KBs are an efficient source of energy that can enter the Krebs cycle bypassing glycolysis

Sources

• Nutrition, Food and Diet in Ageing and Longevity