FGF21
OtherPro-longevity hormone discovered in 2000; increases mouse lifespan 30-40%; boosts AMPK and sirtuins while inhibiting IGF-1 and mTOR; markedly higher in those eating plant-based
Health Benefits
Health conditions that FGF21 may influence, based on research.
Reduces Risk Of
- Premature Death
Increases mouse lifespan by 30-40%, comparable to lifelong caloric restriction
Source: How Not to Age
- Aging
described as pro-longevity hormone
Source: The How Not to Age Cookbook
Protects Against
- Aging
FGF21 extends lifespan in mice; activates AMPK signaling
Source: How Not to Age
- Obesity
FGF21 decreases body weight without reducing food intake in primates
Source: How Not to Age
- Insulin resistance
FGF21 signaling controls insulin signaling to adipose tissue, increasing glucose uptake and insulin signaling.
Source: How We Age
Biological Mechanisms
How FGF21 works at a cellular level.
- InhibitsIGF-1 signaling
At least part of FGF21's lifespan extension seems to be due to its inhibition of insulin-like growth factor 1 (IGF-1) signaling in the liver.
Sources
- How Not to Age
- How We Age
- The How Not to Age Cookbook