Short-Chain Fatty Acids
OtherPostbiotics produced by gut bacteria from fiber; absorbed into bloodstream, circulate throughout body including brain
Health Benefits
Health conditions that Short-Chain Fatty Acids may influence, based on research.
Reduces Risk Of
- Colorectal cancer
Short-chain fatty acids from fiber fermentation play a role in colorectal cancer protection (Tan et al. 2014; Fechner et al. 2013)
Source: How Not to Die
Protects Against
- Aging
SCFAs such as butyrate are produced by the young microbiome and by the beneficial bacteria in probiotics, and have been shown to have some protective effects
Source: How We Age
- Obesity
The SCFA that are not utilized in colon may exert beneficial effects against diet-induced obesity and hyperlipidaemia by interfering with carbohydrate and lipid metabolism
Source: Nutrition, Food and Diet in Ageing and Longevity
Biological Mechanisms
How Short-Chain Fatty Acids works at a cellular level.
- PromotesReduces inflammation
Bacterial species associated with the healthy production of SCFAs, thiamine, and folate; SCFAs are associated with youthfulness and health
- PromotesStimulates Appetite-Regulating Hormone
SCFAs stimulate the secretion of GLP-1, which inhibits glucagon secretion, modulates insulin secretion, improves insulin sensitivity
- PromotesPromotes Mineral Absorption
SCFAs promote mineral absorption, metabolism of glucose and lipids, stimulate proliferation and differentiation of intestinal enterocytes
- InhibitsSystemic Inflammation
- InhibitsInflammaging
Short-chain fatty acids are absorbed and reduce systemic inflammation.
Sources
- How Not to Age
- How Not to Die
- How We Age
- Nutrition, Food and Diet in Ageing and Longevity
- The How Not to Age Cookbook
- Young Forever