Withanone

Food Sources

Foods that contain Withanone.

• Ashwagandha

  Ashwagandha leaves contain Wi-N (Withanone) and Wi-A (Withaferin A) as predominant constituents.

  Source: Nutrition, Food and Diet in Ageing and Longevity

Biological Mechanisms

How Withanone works at a cellular level.

• PromotesProtects cells against oxidative stress and delays cellular aging

  Wi-N treated normal human fibroblasts underwent further 10-12 population doublings, showed 20% less auto-fluorescence and senescence-associated β-gal activity. Wi-N protected cells against UV and oxidative stress.

• PromotesProtects brain cells and promotes their healthy development

  Wi-N caused suppression of ROS and upregulation of MAP2, NF200, PSD-95 and GAP43 proteins advocating for its neuro-protective and differentiation-inducing potential.

Sources

• Nutrition, Food and Diet in Ageing and Longevity