NAD+

Other

Critical cofactor for sirtuin activity; levels can be boosted through AMPK activation

Health Benefits

Health conditions that NAD+ may influence, based on research.

Aging
NAD+ repletion improves mitochondrial and stem cell function and enhances lifespan in mice
Source: How Not to Age
Sarcopenia
Sarcopenic individuals show reduced mitochondrial oxidative capacity and repressed biosynthesis of NAD+; dietary intake of NAD+ precursors such as vitamin B3 and tryptophan can increase NAD+ levels
Source: Nutrition, Food and Diet in Ageing and Longevity
Age-Related Macular Degeneration
NAD is a factor which regulates retinal cell metabolism and homeostasis; exogenous supplementation with NAD plays an important role in therapy and prevention of ARMD through induction of mitophagy and regulation of oxidative stress
Source: Nutrition, Food and Diet in Ageing and Longevity
Biological aging
May be closest to fountain of youth. Supplementation with NAD+ and precursors NR and NMN have restored youthful levels, reversing age-related pathology.
Source: Young Forever

How NAD+ works at a cellular level.

PromotesSirtuin Activation
NAD+ activates DNA repair, inhibits inflammation, and optimizes mitochondrial function via sirtuins.