Nicotinamide Riboside
VitaminNAD+ precursor; only NAD+ booster to prolong mouse lifespan. Boosts blood NAD+ up to 168% but fails to raise muscle NAD+ in humans. No clinical benefit found in human trials.
Health Benefits
Health conditions that Nicotinamide Riboside may influence, based on research.
Improves
- Alzheimer's disease
Restores cognition in Alzheimer's mouse models
Source: How Not to Age
Protects Against
- Obesity
In mice, NR enhanced oxidative metabolism and protected against high-fat diet-induced obesity
Source: How Not to Age
- Age-Related NAD+ Decline
NAD+ levels decline with age, and there is the hope that supplementing with the NAD+ precursor nicotinamide riboside (NR) will help stave off age-related decline.
Source: How We Age
Addresses
- Parkinson's disease
The NADPARK study was a randomized phase I trial of NR supplementation in Parkinson's disease
Source: How Not to Age
Biological Mechanisms
How Nicotinamide Riboside works at a cellular level.
- PromotesReduces inflammation
NR augments the aged human skeletal muscle NAD+ metabolome and induces anti-inflammatory signatures
- PromotesNAD+ Boosting
NR is a precursor to NAD+, and is used by the cell to generate NAD+; this is why you'll see it sold as a supplement to boost cellular levels of NAD+; Nicotinamide riboside (NR) is an NAD+ precursor marketed as a dietary supplement for anti-aging; NAD+ declines with age and is important for sirtuin function
- PromotesActivates or regenerates adult stem cells
Oral administration of NR at 500 mg/kg/day for 6 weeks resulted in intestinal stem cell recovery in aged mice
Sources
- How Not to Age
- How We Age
- Nutrition, Food and Diet in Ageing and Longevity