Age-Related NAD+ Decline

Compounds That May Help

Bioactive compounds linked to Age-Related NAD+ Decline in the research.

• Nicotinamide RibosideProtects against

  NAD+ levels decline with age, and there is the hope that supplementing with the NAD+ precursor nicotinamide riboside (NR) will help stave off age-related decline.

  Source: How We Age

• Nicotinamide MononucleotideProtects against

  Aging is accompanied by a gradual decline in tissue and cellular NAD+ levels; supplementation with NMN is geroprotective

  Source: Nutrition, Food and Diet in Ageing and Longevity

Biological Mechanisms

• Contributes toCD38-Mediated NAD+ Degradation

  CD38-expressing macrophages drive age-related NAD+ decline; CD38 ecto-enzyme in immune cells is induced during aging

Sources

• How Not to Age
• How We Age
• Nutrition, Food and Diet in Ageing and Longevity