Urolithin A
PhytochemicalGut microbiota metabolite of ellagitannins that induces mitophagy, prolongs lifespan in C. elegans, and improves muscle function
Food Sources
Foods that contain Urolithin A.
- Pomegranate
Gallotannin, digallic acid, urolithin from grapes, pomegranate - tannin compounds with longevity effects.
Source: Nutrition, Food and Diet in Ageing and Longevity
Health Benefits
Health conditions that Urolithin A may influence, based on research.
Protects Against
- Aging
Improved muscle endurance and mitochondrial health in older adults
Source: How Not to Age
- Mitochondrial dysfunction
Ellagitannins, which are metabolized into the compound urolithin A, improve mitochondrial function
Source: How We Age
- Sarcopenia
After 4 months, supplement increased leg muscle strength by 12% and VO2max by 10% without exercise.
Source: Young Forever
Improves
- Sarcopenia
Improved muscle endurance and mitochondrial health in older adults (JAMA 2022)
Source: How Not to Age
Biological Mechanisms
How Urolithin A works at a cellular level.
- PromotesInduces mitophagy
Urolithin A induces mitophagy, prolonging lifespan in C. elegans and improving muscle function in rodents and humans
- PromotesAutophagy
Several drugs increase autophagy (e.g., metformin, rapamycin, urolithin A) and improve health in model systems.
- PromotesMitophagy
Urolithin A induces mitophagy and production of more mitochondria.
- InhibitsInflammaging
Lowers systemic inflammation as measured by CRP levels.
Recipes with Urolithin A
Recipes featuring foods that contain Urolithin A.
Sources
- How Not to Age
- Nutrition, Food and Diet in Ageing and Longevity
- How We Age
- Young Forever