Apigenin

Food Sources

Foods that contain Apigenin.

• Celery

  Apigenin occurs in apple, orange, grapefruit, chamomile, celery, parsley, and onion

  Source: Nutrition, Food and Diet in Ageing and Longevity

• Extra-Virgin Olive Oil

  Other phytochemicals present in Hidrox (olive extract) include apigenin, luteolin and elenolic acid

  Source: Nutrition, Food and Diet in Ageing and Longevity

• Parsley

  Source: Young Forever

• Chamomile

  Source: Young Forever

Health Benefits

Health conditions that Apigenin may influence, based on research.

Biological Mechanisms

How Apigenin works at a cellular level.

• PromotesSuppresses NF-kB signaling that drives cancer growth

  Apigenin inhibits activation of NF-kB, which is a transcription factor with crucial role in iNOS and COX-2 expression

• PromotesmTOR Suppression

  Apigenin (oranges, apples, cherries, grapes, onions, parsley, broccoli, sweet green peppers, celery, barley, tomatoes, tea) targets mTOR and PI3K signaling pathways

• PromotesSuppresses the inflammatory secretions of senescent cells (SASP)

  Apigenin suppressed the SASP in three human fibroblast strains induced to senescence; mechanism involves suppression of IL-1alpha signaling through IRAK1/IRAK4, p38-MAPK, and NF-kB

• PromotesInhibits CD38 enzyme that depletes NAD+

  Apigenin is an inhibitor of NAD+ase CD38 enzyme; pro-inflammatory macrophages express high levels of the NAD-consuming enzyme CD38

• SupportsNAD+ Boosting

  Declining tissue NAD levels are linked to aging; apigenin inhibits CD38 which consumes NAD, and targeting NAD+ metabolism has emerged as a potential therapeutic approach

Recipes with Apigenin

Recipes featuring foods that contain Apigenin.

• Olive Oil and Almond Cake
• Roasted Red Pepper and Zucchini Frittata
• Cauliflower Rice Burrito Bowl
• Asparagus Vinaigrette
• Salsa Verde
• Chermoula

Sources

• How Not to Age
• Nutrition, Food and Diet in Ageing and Longevity
• Young Forever