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Genistein

Phytochemical

Soy phytoestrogen structurally similar to estrogen that functions as a natural selective estrogen receptor modulator

Food Sources

Foods that contain Genistein.

  • Soy

    Source: How Not to Age

  • Soybeans

    Genistein from soybean and soy-based foods

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Soy Foods

    Genistein forms a large part of the isoflavone content of soya, perhaps as high as 60%

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Tofu

    Source: Young Forever

  • Natto

    Source: Young Forever

Health Benefits

Health conditions that Genistein may influence, based on research.

Protects Against

  • Osteoporosis

    RCT (Morabito 2002) showing genistein effects on bone loss in early postmenopausal women

    Source: How Not to Age

  • Cardiovascular Disease

    Genistein from soybean and soy-based foods has cardioprotective effects; protects from diabetes and cancer

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Alzheimer's disease

    Genistein has potential to reduce activity of DNA topoisomerase and tyrosine protein kinase; many phenolic moieties lead to good antioxidant activity

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Menopause symptoms

    Genistein modulates postmenopausal symptoms such as hot flushes, anxiety and depression

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Cancer

    Source: Young Forever

Biological Mechanisms

How Genistein works at a cellular level.

  • PromotesActivates Nrf2

    Some well-known phytochemicals which strongly induce Nrf2-mediated SR include curcumin, quercetin, genistein and eugenol.

  • PromotesmTOR Suppression

    Isoflavones genistein (soy) targets mTOR and PI3K pathways

  • PromotesActs as phytoestrogen, modulating estrogen activity

    Soya genistein is an isoflavone (phytoestrogen); improves glucose metabolism, induces apoptosis in cancer, modulates postmenopausal symptoms

  • PromotesDNA methylation

    Mice given methylation factors including genistein produced healthy offspring from genetically identical agouti mice.

Recipes with Genistein

Recipes featuring foods that contain Genistein.

Sources

  • How Not to Age
  • Nutrition, Food and Diet in Ageing and Longevity
  • Young Forever