Genistein
PhytochemicalSoy phytoestrogen structurally similar to estrogen that functions as a natural selective estrogen receptor modulator
Food Sources
Foods that contain Genistein.
- Soy
Source: How Not to Age
- Soybeans
Genistein from soybean and soy-based foods
Source: Nutrition, Food and Diet in Ageing and Longevity
- Soy Foods
Genistein forms a large part of the isoflavone content of soya, perhaps as high as 60%
Source: Nutrition, Food and Diet in Ageing and Longevity
- Tofu
Source: Young Forever
- Natto
Source: Young Forever
Health Benefits
Health conditions that Genistein may influence, based on research.
Protects Against
- Osteoporosis
RCT (Morabito 2002) showing genistein effects on bone loss in early postmenopausal women
Source: How Not to Age
- Cardiovascular Disease
Genistein from soybean and soy-based foods has cardioprotective effects; protects from diabetes and cancer
Source: Nutrition, Food and Diet in Ageing and Longevity
- Alzheimer's disease
Genistein has potential to reduce activity of DNA topoisomerase and tyrosine protein kinase; many phenolic moieties lead to good antioxidant activity
Source: Nutrition, Food and Diet in Ageing and Longevity
- Menopause symptoms
Genistein modulates postmenopausal symptoms such as hot flushes, anxiety and depression
Source: Nutrition, Food and Diet in Ageing and Longevity
- Cancer
Source: Young Forever
Biological Mechanisms
How Genistein works at a cellular level.
- PromotesActivates Nrf2
Some well-known phytochemicals which strongly induce Nrf2-mediated SR include curcumin, quercetin, genistein and eugenol.
- PromotesmTOR Suppression
Isoflavones genistein (soy) targets mTOR and PI3K pathways
- PromotesActs as phytoestrogen, modulating estrogen activity
Soya genistein is an isoflavone (phytoestrogen); improves glucose metabolism, induces apoptosis in cancer, modulates postmenopausal symptoms
- PromotesDNA methylation
Mice given methylation factors including genistein produced healthy offspring from genetically identical agouti mice.
Recipes with Genistein
Recipes featuring foods that contain Genistein.
Sources
- How Not to Age
- Nutrition, Food and Diet in Ageing and Longevity
- Young Forever
