Fisetin
PhytochemicalA flavonoid found concentrated in strawberries; nearly twice as potent a senolytic as quercetin. Extended average and maximum lifespans of older mice by about 75% when started at the equivalent of age 75 in humans.
Food Sources
Foods that contain Fisetin.
- Strawberries
Strawberries are the richest known dietary source of fisetin.
Source: How Not to Age
- Apples
Fisetin is present in strawberries, apples, persimmons, grapes, onions, kiwi, kale, nuts
Source: Nutrition, Food and Diet in Ageing and Longevity
- Persimmons
Fisetin is present in strawberries, apples, persimmons, grapes, onions, kiwi, kale, nuts
Source: Nutrition, Food and Diet in Ageing and Longevity
- Grapes
Fisetin is present in strawberries, apples, persimmons, grapes, onions, kiwi, kale, nuts
Source: Nutrition, Food and Diet in Ageing and Longevity
- Onions
Fisetin is present in strawberries, apples, persimmons, grapes, onions, kiwi, kale, nuts
Source: Nutrition, Food and Diet in Ageing and Longevity
- Kiwifruit
Fisetin is present in strawberries, apples, persimmons, grapes, onions, kiwi, kale, nuts
Source: Nutrition, Food and Diet in Ageing and Longevity
- Kale
Fisetin is present in strawberries, apples, persimmons, grapes, onions, kiwi, kale, nuts
Source: Nutrition, Food and Diet in Ageing and Longevity
- Strawberry
Source: Young Forever
Health Benefits
Health conditions that Fisetin may influence, based on research.
Protects Against
- Aging
When given to wild-type mice late in life, fisetin restored tissue homeostasis, reduced age-related pathologies, and extended median and maximum lifespan
Source: Nutrition, Food and Diet in Ageing and Longevity
- Cellular senescence
Fisetin selectively induces apoptosis in senescent but not proliferating human umbilical vein endothelial cells
Source: Nutrition, Food and Diet in Ageing and Longevity
Biological Mechanisms
How Fisetin works at a cellular level.
- InhibitsCellular senescence
Nearly twice as potent a senolytic as quercetin. Extended average/maximum lifespans of older mice by ~75% when started at equivalent of age 75.
- PromotesClears senescent (zombie) cells
Fisetin is a senotherapeutic that extends health and lifespan. Found in apples, grapes, strawberries.; Fisetin was found to be the most potent senolytic in a panel of ten flavonoid polyphenols using senescent mouse and human cells
- PromotesSirtuin Activation
SIRT1 activators include fisetin (fresh cucumbers, strawberries)
- PromotesmTOR Suppression
Several polyphenols have been found to inhibit or influence mTOR, such as fisetin
- InhibitsInflammaging
Fisetin is a senolytic compound that kills zombie cells.
- PromotesAutophagy
- PromotesAMPK activation
- PromotesCalorie Restriction Mimicry
Recipes with Fisetin
Recipes featuring foods that contain Fisetin.
- Okinawa-Inspired Smoothie
- Millet Brunch Cake with Strawberries
- Quinoa, Strawberry, and Sunchoke Salad
- Strawberry and Basil Refresher
- Roasted Rhubarb-Strawberry Coconut Crumble
- Lemon-Ginger Apple Chews
- Braised Red Cabbage with Apples and Walnuts
- Paleo Trail-Mix Muffins
- Vegetable Broth 2.0
- Dr. Fuhrman's Anti-Inflammatory Green Smoothie
- Lasagna with Kale and Red Lentil Tomato Sauce
- Kale and Millet-Stuffed Bell Peppers
- Kasha with Purple Sweet Potatoes and Kale
- Winter Vegetable Stew
- Kimchi, Egg, and Avocado Bowl
- Oven-Baked Miso Kale Chips
- Tex-Mex Breakfast Bake
- Chickpea Chop Salad with Whipped Jalapeno Feta
- Chicken with Kale and Preserved Lemon
Sources
- How Not to Age
- Nutrition, Food and Diet in Ageing and Longevity
- Young Forever