Omega-3 fatty acids
Fatty AcidFound in fish; scores as anti-inflammatory in the Dietary Inflammatory Index but only appears to help among those with chronic disease. Fish oil supplements in healthy people showed no benefit.
Food Sources
Foods that contain Omega-3 fatty acids.
- Walnuts
Source: How Not to Age
- Ground Flaxseed
Flaxseeds contain omega-3 fatty acids that are not destroyed by baking
Source: How Not to Die
- Algae
I recommend taking 250 mg of pollutant-free long-chain omega-3s directly from algae, which is where the fish primarily get it from to begin with
Source: How Not to Die
- Fish
Fish are sources of high quality proteins, healthy lipids (e.g. omega-3 oils in fish)
Source: Nutrition, Food and Diet in Ageing and Longevity
- Fatty fish
Fatty fish species such as salmon, herring and mackerel are rich in omega-3 fatty acids and vitamin D, and intake is related to improved physical functioning in older adults
Source: Nutrition, Food and Diet in Ageing and Longevity
- Flaxseeds
Major sources of omega-3 fatty acids are flaxseed and seafood; Seeds/nuts (walnuts, flaxseed, soya bean, canola) recommended as omega-3 sources
Source: Nutrition, Food and Diet in Ageing and Longevity
- Fatty Fish
A diet rich in cold-water fatty fish (herring, tuna, sardines, salmon, mackerel), seeds/nuts (walnuts, flaxseed) recommended for omega-3
Source: Nutrition, Food and Diet in Ageing and Longevity
- Salmon
Source: The Longevity Diet
- Anchovies
Source: The Longevity Diet
- Sardines
Source: The Longevity Diet
- Cod
Source: The Longevity Diet
- Trout
Source: The Longevity Diet
- Pecorino cheese
High omega-3 cheese made from ewe's milk, consumed by long-lived Sardinians
Source: The Longevity Diet
- Linseed oil
Used as omega-3 supplement in MS clinical trial FMD protocol
Source: The Longevity Diet
- Eggs
filled with omega-3 fats, iron, vitamins A and D, folate, and choline
Source: The Young Forever Cookbook
- Bison
two essential fatty acids, omega-3 and omega-6
Source: The Young Forever Cookbook
- Mussels
iron, and omega-3 fatty acids
Source: The Young Forever Cookbook
- Scallops
anti-inflammatory omega-3 fatty acids, all of which contribute to a healthier immune system and improved cognitive health
Source: The Young Forever Cookbook
- Fish oil
Source: Young Forever
- Krill Oil
Source: Young Forever
Health Benefits
Health conditions that Omega-3 fatty acids may influence, based on research.
Protects Against
- Telomere Shortening
Marine omega-3 fatty acid levels associated with slower telomeric aging; supplementation may attenuate telomere shortening in elderly with cognitive impairment
Source: How Not to Age
- Cognitive decline
Omega-3 PUFA are associated with decrease in the cognitive performance decline associated with aging (Almeida et al. 2021)
Source: Nutrition, Food and Diet in Ageing and Longevity
- Bone mineral density loss
Omega-3 PUFA are associated with the maintenance of bone health and muscle tone
Source: Nutrition, Food and Diet in Ageing and Longevity
- Sarcopenia
Omega-3 fatty acids have anti-inflammatory properties targeting inflammageing; can attenuate anabolic resistance by improving insulin sensitivity and endothelial functioning; when combined with protein, can improve muscle mass and functioning in older adults
Source: Nutrition, Food and Diet in Ageing and Longevity
- Osteoarthritis
Supplementation with omega-3 fatty acids is associated with decreased pain and improvement of function through modulation of apoptosis, reduction of oxidative stress and decrease in prostaglandin production
Source: Nutrition, Food and Diet in Ageing and Longevity
- Age-Related Macular Degeneration
Decreased omega-6/omega-3 ratio protects against neovascular ARMD; increasing intake of omega-3 fatty acids should be the aim of dietary interventions for ARMD
Source: Nutrition, Food and Diet in Ageing and Longevity
- Parkinson's disease
Principal factors in nutrition-related approaches to Parkinson's include omega fatty acids.
Source: Nutrition, Food and Diet in Ageing and Longevity
- Aging
There are certain pluripotent nutrients that can be recommended in most conditions including omega-3 acids.
Source: Nutrition, Food and Diet in Ageing and Longevity
- Alzheimer's disease
Other potential interventions that have shown some promise include lowering homocysteine with B vitamins, while optimizing omega-3 fatty acids; Optimizing omega-3 fatty acids discussed as part of Alzheimer's prevention strategy alongside B vitamins and other interventions
Source: Outlive
- Dementia
Deficiency in omega-3 implicated in brain aging and dementias
Source: The Longevity Diet
- Heart disease
Source: Young Forever
Reduces Risk Of
- Cardiovascular Disease
Multiple large RCTs (Bowman 2018, Manson 2019, Nicholls 2020) found limited or no benefit of omega-3 supplements for CVD prevention
Source: How Not to Age
- Cancer
Omega-3 fatty acids show benefits in prevention of cardiovascular disease, cancer and metabolic syndrome
Source: Nutrition, Food and Diet in Ageing and Longevity
- Heart disease
PUFA DHA/EPA from fish oils support heart health and may reduce the risk of coronary heart disease
Source: Nutrition, Food and Diet in Ageing and Longevity
Improves
- Heart disease
Improve endothelial function and prevent dangerous clotting.
Source: Young Forever
- Dementia
Cognitive support
Source: Young Forever
Biological Mechanisms
How Omega-3 fatty acids works at a cellular level.
- PromotesReduces inflammation
Scores as anti-inflammatory in Dietary Inflammatory Index but only helps those with chronic disease. Fish oil supplements in healthy people showed no benefit.
- PromotesLowers Triglycerides
Omega-3 PUFA associated with inhibition of triglyceride synthesis in the liver
- PromotesSlows Cellular Aging
Omega-3 FAs attenuate cellular senescence of immune cells via telomere shortening and inhibition of SASP
- PromotesOvercomes age-related resistance to muscle building
Omega-3 fatty acids can attenuate anabolic resistance by improving insulin sensitivity and endothelial functioning; when combined with protein and amino acids, can improve muscle mass and functioning in older adults
- PromotesReduces neuroinflammation
Optimizing omega-3 fatty acids may reduce neuroinflammation; APOE e4 carriers show higher neuroinflammation (Kloske and Wilcock 2020)
- PromotesSlows Brain Atrophy
Optimizing omega-3 fatty acids while lowering homocysteine with B vitamins may slow brain atrophy (Oulhaj et al. 2016)
- InhibitsInflammaging
Omega-3 fats and resolvins help lower overall inflammation.
- PromotesCalorie Restriction Mimicry
Recipes with Omega-3 fatty acids
Recipes featuring foods that contain Omega-3 fatty acids.
- Eight Check-Mark Pesto
- Nutty Parm 2.0
- Groatnola Plus
- Lentil-Walnut Burgers with Cheesy Sauce
- Spiralized Zucchini Noodles with Spinach-Walnut Pesto
- Basil Pesto
- Braised Red Cabbage with Apples and Walnuts
- Mixed Berry Crumble
- Blueberry Chia Pie
- Banana-Walnut Cake with Blackberry-Almond Butter Sauce
- Cocoa-Almond Butter Cookies
- Raw Chocolate Tart
- Basil Walnut Pesto
- Savory Breakfast Salad
- Smoky Roasted Pepper and Walnut Dip
- Bitter Greens with Steak and Romesco Sauce
- Asparagus Vinaigrette
- Trail-Mix Energy Cookies
- Okinawa-Inspired Smoothie
- Flax Crackers
- Dr. Fuhrman's Anti-Inflammatory Green Smoothie
- Chickpea and Tempeh Breakfast Burritos
- Baked Carrot Cake Oatmeal
- Protein Powerhouse Smoothie
- Super-Seed Quinoa Crackers
- Paleo Trail-Mix Muffins
- Broccoli and Quinoa Slaw with Wild Salmon and Hemp Pesto
- Forbidden Rice and Salmon Poke Bowl
- Salmon with Fennel and Citrus Salad
- Tomato and Sardine Crisps
- Wild Rice Bowl with Smoked Trout and Coconut Cucumber Salad
- Roasted Red Pepper and Zucchini Frittata
- Brussels Sprouts with Pecorino and Hazelnuts
- Cauliflower Gratin
- Kimchi, Egg, and Avocado Bowl
- Soft Herb and Mushroom Omelet
- Tex-Mex Breakfast Bake
- Sweet Potato and Egg Stacks
- Tempeh Sausage with Eggs and Roasted Tomatoes
- Egg Snack Pots, Three Ways
- Coconut Cobb Salad
- Chipotle Bison Chili
- Bison Meatballs with Braised White Beans
- Mussels with Lemongrass and Ginger Broth
- Seared Scallops with Bursting Tomatoes
Sources
- How Not to Age
- How Not to Die
- Nutrition, Food and Diet in Ageing and Longevity
- The Longevity Diet
- The Young Forever Cookbook
- Young Forever
- Outlive
