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Omega-3 fatty acids

Fatty Acid

Found in fish; scores as anti-inflammatory in the Dietary Inflammatory Index but only appears to help among those with chronic disease. Fish oil supplements in healthy people showed no benefit.

Food Sources

Foods that contain Omega-3 fatty acids.

  • Walnuts

    Source: How Not to Age

  • Ground Flaxseed

    Flaxseeds contain omega-3 fatty acids that are not destroyed by baking

    Source: How Not to Die

  • Algae

    I recommend taking 250 mg of pollutant-free long-chain omega-3s directly from algae, which is where the fish primarily get it from to begin with

    Source: How Not to Die

  • Fish

    Fish are sources of high quality proteins, healthy lipids (e.g. omega-3 oils in fish)

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Fatty fish

    Fatty fish species such as salmon, herring and mackerel are rich in omega-3 fatty acids and vitamin D, and intake is related to improved physical functioning in older adults

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Flaxseeds

    Major sources of omega-3 fatty acids are flaxseed and seafood; Seeds/nuts (walnuts, flaxseed, soya bean, canola) recommended as omega-3 sources

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Fatty Fish

    A diet rich in cold-water fatty fish (herring, tuna, sardines, salmon, mackerel), seeds/nuts (walnuts, flaxseed) recommended for omega-3

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Salmon

    Source: The Longevity Diet

  • Anchovies

    Source: The Longevity Diet

  • Sardines

    Source: The Longevity Diet

  • Cod

    Source: The Longevity Diet

  • Trout

    Source: The Longevity Diet

  • Pecorino cheese

    High omega-3 cheese made from ewe's milk, consumed by long-lived Sardinians

    Source: The Longevity Diet

  • Linseed oil

    Used as omega-3 supplement in MS clinical trial FMD protocol

    Source: The Longevity Diet

  • Eggs

    filled with omega-3 fats, iron, vitamins A and D, folate, and choline

    Source: The Young Forever Cookbook

  • Bison

    two essential fatty acids, omega-3 and omega-6

    Source: The Young Forever Cookbook

  • Mussels

    iron, and omega-3 fatty acids

    Source: The Young Forever Cookbook

  • Scallops

    anti-inflammatory omega-3 fatty acids, all of which contribute to a healthier immune system and improved cognitive health

    Source: The Young Forever Cookbook

  • Fish oil

    Source: Young Forever

  • Krill Oil

    Source: Young Forever

Health Benefits

Health conditions that Omega-3 fatty acids may influence, based on research.

Protects Against

  • Telomere Shortening

    Marine omega-3 fatty acid levels associated with slower telomeric aging; supplementation may attenuate telomere shortening in elderly with cognitive impairment

    Source: How Not to Age

  • Cognitive decline

    Omega-3 PUFA are associated with decrease in the cognitive performance decline associated with aging (Almeida et al. 2021)

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Bone mineral density loss

    Omega-3 PUFA are associated with the maintenance of bone health and muscle tone

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Sarcopenia

    Omega-3 fatty acids have anti-inflammatory properties targeting inflammageing; can attenuate anabolic resistance by improving insulin sensitivity and endothelial functioning; when combined with protein, can improve muscle mass and functioning in older adults

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Osteoarthritis

    Supplementation with omega-3 fatty acids is associated with decreased pain and improvement of function through modulation of apoptosis, reduction of oxidative stress and decrease in prostaglandin production

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Age-Related Macular Degeneration

    Decreased omega-6/omega-3 ratio protects against neovascular ARMD; increasing intake of omega-3 fatty acids should be the aim of dietary interventions for ARMD

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Parkinson's disease

    Principal factors in nutrition-related approaches to Parkinson's include omega fatty acids.

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Aging

    There are certain pluripotent nutrients that can be recommended in most conditions including omega-3 acids.

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Alzheimer's disease

    Other potential interventions that have shown some promise include lowering homocysteine with B vitamins, while optimizing omega-3 fatty acids; Optimizing omega-3 fatty acids discussed as part of Alzheimer's prevention strategy alongside B vitamins and other interventions

    Source: Outlive

  • Dementia

    Deficiency in omega-3 implicated in brain aging and dementias

    Source: The Longevity Diet

  • Heart disease

    Source: Young Forever

Reduces Risk Of

  • Cardiovascular Disease

    Multiple large RCTs (Bowman 2018, Manson 2019, Nicholls 2020) found limited or no benefit of omega-3 supplements for CVD prevention

    Source: How Not to Age

  • Cancer

    Omega-3 fatty acids show benefits in prevention of cardiovascular disease, cancer and metabolic syndrome

    Source: Nutrition, Food and Diet in Ageing and Longevity

  • Heart disease

    PUFA DHA/EPA from fish oils support heart health and may reduce the risk of coronary heart disease

    Source: Nutrition, Food and Diet in Ageing and Longevity

Improves

  • Heart disease

    Improve endothelial function and prevent dangerous clotting.

    Source: Young Forever

  • Dementia

    Cognitive support

    Source: Young Forever

Biological Mechanisms

How Omega-3 fatty acids works at a cellular level.

  • PromotesReduces inflammation

    Scores as anti-inflammatory in Dietary Inflammatory Index but only helps those with chronic disease. Fish oil supplements in healthy people showed no benefit.

  • PromotesLowers Triglycerides

    Omega-3 PUFA associated with inhibition of triglyceride synthesis in the liver

  • PromotesSlows Cellular Aging

    Omega-3 FAs attenuate cellular senescence of immune cells via telomere shortening and inhibition of SASP

  • PromotesOvercomes age-related resistance to muscle building

    Omega-3 fatty acids can attenuate anabolic resistance by improving insulin sensitivity and endothelial functioning; when combined with protein and amino acids, can improve muscle mass and functioning in older adults

  • PromotesReduces neuroinflammation

    Optimizing omega-3 fatty acids may reduce neuroinflammation; APOE e4 carriers show higher neuroinflammation (Kloske and Wilcock 2020)

  • PromotesSlows Brain Atrophy

    Optimizing omega-3 fatty acids while lowering homocysteine with B vitamins may slow brain atrophy (Oulhaj et al. 2016)

  • InhibitsInflammaging

    Omega-3 fats and resolvins help lower overall inflammation.

  • PromotesCalorie Restriction Mimicry

Recipes with Omega-3 fatty acids

Recipes featuring foods that contain Omega-3 fatty acids.

Sources

  • How Not to Age
  • How Not to Die
  • Nutrition, Food and Diet in Ageing and Longevity
  • The Longevity Diet
  • The Young Forever Cookbook
  • Young Forever
  • Outlive